Role of Phospholipases in Regulation of Cardiolipin Biosynthesis and Remodeling in the Heart and Mammalian Cells
نویسندگان
چکیده
P.S. Tappia and N.S. Dhalla (eds.), Phospholipases in Health and Disease, Advances in Biochemistry in Health and Disease 10, DOI 10.1007/978-1-4939-0464-8_2, © Springer Science+Business Media New York 2014 Abstract Cardiolipin is a key mitochondrial membrane phospholipid involved in the regulation of generation of ATP. Cardiolipin synthesis and remodeling are tightly regulated processes in eukaryotic cells. The role of phospholipases in the regulation of cardiolipin metabolism is becoming much clearer. Cardiolipin is hydrolysed by several classes of phospholipases including calcium-independent phospholipase A 2 , secretory phospholipase A 2 , and cytosolic phospholipase A 2 . Mitochondrial calcium-independent phospholipase A 2 gamma has emerged as a key player not only in the regulated hydrolysis of cardiolipin to monolysocardiolipin, but also in the overall regulation of mitochondrial function and energy production. The purpose of this chapter is to summarize some of the more current fi ndings on the role of phospholipases in the regulation of cardiolipin metabolism in the heart and mammalian tissues. In addition, a brief discussion on the role of exogenous phospholipase-treatment of cells on cardiolipin metabolism is presented. Chapter 2 Role of Phospholipases in Regulation of Cardiolipin Biosynthesis and Remodeling in the Heart and Mammalian Cells
منابع مشابه
Focal Adhesion Kinase (FAK) Involvement in Human Endometrial Remodeling During the Menstrual Cycle
Background: Endometrial remodeling occurs during each menstrual cycle in women. Reports have shown that, in a variety of cell types, processes such as proliferation, signaling complex formation and extra cellular matrix remodeling require a cytoplasmic tyrosine kinase, focal adhesion kinase (FAK). The present study has focused on the expression pattern of FAK in human endometrium during the men...
متن کاملRecent Advances in T Cell Signaling in Aging
The immune system of mammalian organisms undergoes alterations that may account for an increased susceptibility to certain infections, autoimmune diseases, or malignancies. Well characterized are age related defect in T cell functions and cell mediated immunity. Although it is well established that the functional properties of T cells decrease with age, its biochemical and molecular nature is...
متن کاملEffects of Taurine, Sestrin 2 and Phyllanthin on coronary artery diseases
Heart failure is a growing epidemic in the worldwide. Atherosclerosis is a major mechanism of cardiovascular disease including myocardial infarction and peripheral arterial disease. Moreover, it causes many diseases and deaths around the world. Atherosclerosis, like coronary artery disease (CAD), is associated with inflammation and oxidative stress. The current article has been collected the s...
متن کاملStereo-Specific Transcript Regulation of the Polyamine Biosynthesis Genes by Enantiomers of Ornithine in Tobacco Cell Culture
Background: Ornithine (Orn) plays an essential role in the metabolism of plant cells through incorporation in polyamines biosynthesis, the urea cycle and nitrogen metabolism. Physiological response of the plant cells to its two enantiomers have not been widely investigated yet.Objectives: This study aimed to evaluate effect of ornithine enantiomers on exp...
متن کاملDysregulation of cardiolipin biosynthesis in pediatric heart failure.
Cardiolipin, a unique phospholipid in the inner mitochondrial membrane, is critical for optimal mitochondrial function. CL abnormalities have been demonstrated in the failing rodent and adult human heart. The aim of this study was to determine whether abnormalities in CL content and the CL biosynthesis and remodeling pathways are present in pediatric idiopathic dilated cardiomyopathy (IDC). A c...
متن کامل